International Journal of Gerontology
Volume 4, Issue 2 , Pages 82-88 , June 2010

Middle-aged Subjects With Habitual Low-speed Cycling Exercise Have Greater Mononuclear Cell Responsiveness Against Human Hepatitis B Virus Surface Antigen

  • Kuen-Chang Hsieh

      Affiliations

    • Research Center, Charder Electronic Co., Ltd, Taipei, Taiwan
    • ,
  • Yu-Yawn Chen

      Affiliations

    • Co-first author
    • Department of Physical Education, National Taiwan Sport University, Taipei, Taiwan
    • ,
  • Tsong-Rong Jang

      Affiliations

    • Department of Physical Education, National Taiwan Sport University, Taipei, Taiwan
    • ,
  • Yu-Jen Chen

      Affiliations

    • Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan
    • Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
    • Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Yu-Jen Chen, Department of Radiation Oncology, Mackay Memorial Hospital, 92, Chung San North Road, Section 2, Taipei 104, Taiwan

,Accepted 25 September 2009.

References 

  1. Andersen LB , Schnohr P , Schroll M , et al.   All-cause mortality associated with physical activity during leisure time, work, sports, and cycling to work . Arch Intern Med . 2000;160:1621–1628
  2. Barengo NC , Hu G , Lakka TA , et al.   Low physical activity as a predictor for total and cardiovascular disease mortality in middle aged men and women in Finland . Eur Heart J . 2004;25:2204–2211
  3. Akimoto T , Kumai Y , Akama T , et al.   Effects of 12 months of exercise training on salivary secretory IgA levels in elderly subjects . Br J Sports Med . 2003;37:76–79
  4. Nieman DC . Exercise, upper respiratory tract infection, and the immune system . Med Sci Sports Exerc . 1994;26:128–139
  5. Shephard RJ , Shek PN . Exercise, aging and immune function . Int J Sports Med . 1995;16:1–6
  6. Flynn MG , Fahlman M , Braun WA , et al.   Effects of resistance training on selected indexes of immune function in elderly women . J Appl Physiol . 1999;86:1905–1913
  7. Mazzeo RS . The influence of exercise and aging on immune function . Med Sci Sports Exerc . 1994;26:586–592
  8. Houston MS , Silverstein MD , Suman VJ . Risk factors for 30-day mortality in elderly patients with lower respiratory tract infection . Arch Intern Med . 1997;157:2190–2195
  9. Shinkai S , Kohno H , Kimura K , et al.   Physical activity and immune senescence in men . Med Sci Sports Exerc . 1995;27:1516–1526
  10. Crist DM , Mackinnon LT , Thompson RF , et al.   Physical exercise increases natural cellular-mediated tumor cytotoxicity in elderly women . Gerontology . 1989;35:66–71
  11. Kohut ML , Arntson BA , Lee W , et al.   Moderate exercise improves antibody response to influenza immunization in older adults . Vaccine . 2004;22:2298–2306
  12. Davis JM , Murphy EA , Brown AS , et al.   Effects of moderate exercise and oat b-glucan on innate immune function and susceptibility to respiratory infection . Am J Physiol Regul Integr Comp Physiol . 2003;286:R366–R372
  13. Suri D , Schilling R , Lopes AR , et al.   Non-cytolytic inhibition of hepatitis B virus replication in human hepatocytes . J Hepatol . 2001;35:790–797
  14. Hsu HY , Chang MH , Ni YH , et al.   Cytokine release of peripheral blood mononuclear cells in children with chronic hepatitis B virus infection . J Pediatr Gastroenterol Nutr . 1999;29:540–545
  15. Moldoveanu AI , Shephard RJ , Shek PN . Exercise elevates plasma levels but not gene expression of IL-1b, IL-6, and TNF-a in blood mononuclear cells . J Appl Physiol . 2000;89:1499–1504
  16. Knowles BB , Howe CC , Aden DP . Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen . Science . 1980;209:497–501
  17. Twist EM , Clark HF , Aden DP , et al.   Integration pattern of hepatitis B virus DNA sequences in human hepatoma cell lines . J Virol . 1981;37:239–241
  18. Mosmann T . Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays . J Immunol Methods . 1983;65:55–63
  19. Chen YY , Chang HM . Antiproliferative and differentiating effects of polysaccharide fraction from Fu-Ling (Poria cocos) on human leukemic U937 and HL-60 cells source . Food Chem Toxicol . 2004;42:759–769
  20. Chen YJ , Shiao MS , Lee SS , et al.   Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells . Life Sci . 1997;60:2349–2359
  21. Chiang J , Huang YW , Chen ML , et al.   Comparison of anti-leukemic immunity against U937 cells in endurance athletes versus sedentary controls . Int J Sports Med . 2000;21:602–607
  22. Liao HF , Chiang LM , Yen CC , et al.   Effect of a periodized exercise training and active recovery program on antitumor activity and development of dendritic cells . J Sports Med Phys Fitness . 2006;46:307–314
  23. Wang SY , Hsu ML , Hsu HC , et al.   The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes . Int J Cancer . 1997;70:699–705
  24. Czaja AJ . Serologic markers of hepatitis A and B in acute and chronic liver disease . Mayo Clin Proc . 1979;54:721–732
  25. Chisari FV . Cytotoxic T cells and viral hepatitis . J Clin Invest . 1997;99:1472–1477
  26. Lee WM . Hepatitis B virus infection . N Engl J Med . 1997;337:1733–1745
  27. Yang HI , Lu SN , Liaw YF , et al.   Hepatitis B e antigen and the risk of hepatocellular carcinoma . N Engl J Med . 2002;347:168–174
  28. Lowder T , Padgett DA , Woods JA . Moderate exercise protects mice from death due to influenza virus . Brain Behav Immun . 2005;19:377–380
  29. Bonino F , Rosina F , Rizzetto M , et al.   Chronic hepatitis in HBsAg carriers with serum HBV-DNA and anti-HBe . Gastroenterology . 1986;90:1268–1273
  30. Mahrle G , Schulze HJ . Recombinant interferon-gamma (rIFN-gamma) in dermatology . J Invest Dermatol . 1990;95(6 Suppl):132S–137S
  31. Schultz U , Chisari FV . Recombinant duck interferon gamma inhibits duck hepatitis B virus replication in primary hepatocytes . J Virol . 1999;73:3162–3168
  32. Sheron N , Lau J , Daniels H , et al.   Increased production of tumour necrosis factor alpha in chronic hepatitis B virus infection . J Hepatol . 1991;12:241–245
  33. Biermer M , Puro R , Schneider RJ . Tumor necrosis factor alpha inhibition of hepatitis B virus replication involves disruption of capsid integrity through activation of NF-kB . J Virol . 2003;77:4033–4042
  34. Romero R , Lavine JE . Cytokine inhibition of the hepatitis B virus core promoter . Hepatology . 1996;23:17–23
  35. Perrillo RP , Schiff ER , Davis GL , et al.   A randomized, controlled trial of interferon alpha-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. The Hepatitis Interventional Therapy Group . N Engl J Med . 1990;323:295–301
  36. van Zonneveld M , Honkoop P , Hansen BE , et al.   Long-term follow-up of alpha-interferon treatment of patients with chronic hepatitis B . Hepatology . 2004;39:804–810
  37. Leibson PJ , Hunter-Laszlo M , Hayward AR . Inhibition of herpes simplex virus type 1 replication in fibroblast cultures by human blood mononuclear cells . J Virol . 1986;57:976–982

PII: S1873-9598(10)70028-4

doi: 10.1016/S1873-9598(10)70028-4

International Journal of Gerontology
Volume 4, Issue 2 , Pages 82-88 , June 2010

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