Cholestasis and Acute Cholecystitis in Hyperthyroidism Treated With Methimazole

Accepted 11 March 2009.

Summary

Hepatic dysfunction and jaundice are usually present in patients with hyperthyroidism. It may be the clinical manifestation of the disease or the adverse effect of antithyroid therapy. We report a 69-year-old male with hyperthyroidism who developed cholestasis and acute cholecystitis after a 4-day course of methimazole. After withdrawal of methimazole, his cholestasis subsided.

Key Words: acute cholecystitis , cholestasis , hyperthyroidism , methimazole

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Article Outline

• Summary

• References

• Copyright

References

1. 1 Davies TF , Larsen PR . Thyrotoxicosis . In: Kronenberg HM , Melmed S , Polonsky KS , et al. editor. Williams Textbook of Endocrinology . 11th edition. Philadelphia: Saunders Elsevier; 2008;p. 336 .

2. 2 Arab DM , Malatjalian DA , Rittmaster RS . Severe cholestatic jaundice in uncomplicated hyperthyroidism treated with methimazole . J Clin Endocrinol Metab . 1995;80:1083–1085 . CrossRef

3. 3 Habershon SO . Exophthalmic goiter, heart disease, jaundice, death . Lancet . 1874;103:510 . CrossRef

4. 4 Chawla M , Bal CS . Four cases of coexistent thyrotoxicosis and jaundice: results of radioiodine treatment and a brief review . Thyroid . 2008;18:289–292 . CrossRef

5. 5 Johnson PJ . The effect of endocrine disease on liver function . In: Bircher J , Benhamou JP , McIntyre N , et al. editor. Oxford Textbook of Clinical Hepatology . Oxford: Oxford Medical Publications; 1991;p. 1195 .

6. 6 Greenspan FS . The thyroid gland . In: Greenspan FS , Gardner DG editor. Basic and Clinical Endocrinology . 7th edition. New York: McGraw-Hill; 2004;p. 227–231 .

7. 7 Ohshima T , Maeda H , Takayasu T , et al. [An autopsy case of sudden death due to hyperthyroidism] . Nihon Hoigaku Zasshi . 1990;44:365–370 [In Japanese] . MEDLINE

8. 8 Owen PJD , Baghomian A , Lazarus JH , et al. An unusual case of jaundice . BMJ . 2007;335:773–774 .

9. 9 Nobili V , Liaskos C , Luigi G , et al. Autoimmune thyroiditis associated with autoimmune hepatitis . Thyroid . 2005;15:1193–1195 . MEDLINE | CrossRef

10. 10 Lee TM , Kuo SH , Lee YT . Reversible systolic heart failure and deep jaundice in hyperthyroidism . Am J Med Sci . 1996;312:246–248 . MEDLINE | CrossRef

11. 11 Cooper DS . Treatment of thyrotoxicosis . In: Braverman LE , Utiger RD , Werner SC , et al. editor. The Thyroid . 7th edition. Philadelphia: Lippincott-Raven; 1996;p. 474 .

12. 12 Cooper DS . Antithyroid drugs . N Engl J Med . 2005;352:905–917 . CrossRef

a Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei, Taiwan

b Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan

c Mackay Medicine, Nursing and Management College, Taipei, Taiwan

Correspondence to: Dr Wei-Che Chen, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mackay Memorial Hospital, 92, Section 2, Chung-Shan North Road, Taipei, Taiwan

PII: S1873-9598(10)70009-0

doi:10.1016/S1873-9598(10)70009-0

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