Volume 3, Issue 4 , Pages 248-250, December 2009
Cholestasis and Acute Cholecystitis in Hyperthyroidism Treated With Methimazole
Article Outline
Summary
Hepatic dysfunction and jaundice are usually present in patients with hyperthyroidism. It may be the clinical manifestation of the disease or the adverse effect of antithyroid therapy. We report a 69-year-old male with hyperthyroidism who developed cholestasis and acute cholecystitis after a 4-day course of methimazole. After withdrawal of methimazole, his cholestasis subsided.
Key Words: acute cholecystitis , cholestasis , hyperthyroidism , methimazole
No full text is available. To read the body of this article, please view the PDF online.
References
- . Thyrotoxicosis . In: Kronenberg HM , Melmed S , Polonsky KS , et al. editor. Williams Textbook of Endocrinology . 11th edition. Philadelphia: Saunders Elsevier; 2008;p. 336
- . Severe cholestatic jaundice in uncomplicated hyperthyroidism treated with methimazole . J Clin Endocrinol Metab . 1995;80:1083–1085
- . Exophthalmic goiter, heart disease, jaundice, death . Lancet . 1874;103:510
- . Four cases of coexistent thyrotoxicosis and jaundice: results of radioiodine treatment and a brief review . Thyroid . 2008;18:289–292
- . The effect of endocrine disease on liver function . In: Bircher J , Benhamou JP , McIntyre N , et al. editor. Oxford Textbook of Clinical Hepatology . Oxford: Oxford Medical Publications; 1991;p. 1195
- . The thyroid gland . In: Greenspan FS , Gardner DG editor. Basic and Clinical Endocrinology . 7th edition. New York: McGraw-Hill; 2004;p. 227–231
- [An autopsy case of sudden death due to hyperthyroidism] . Nihon Hoigaku Zasshi . 1990;44:365–370 [In Japanese]
- An unusual case of jaundice . BMJ . 2007;335:773–774
- Autoimmune thyroiditis associated with autoimmune hepatitis . Thyroid . 2005;15:1193–1195
- . Reversible systolic heart failure and deep jaundice in hyperthyroidism . Am J Med Sci . 1996;312:246–248
- . Treatment of thyrotoxicosis . In: Braverman LE , Utiger RD , Werner SC , et al. editor. The Thyroid . 7th edition. Philadelphia: Lippincott-Raven; 1996;p. 474
- . Antithyroid drugs . N Engl J Med . 2005;352:905–917
PII: S1873-9598(10)70009-0
doi:10.1016/S1873-9598(10)70009-0
© 2009 Elsevier B.V. All rights reserved.
Volume 3, Issue 4 , Pages 248-250, December 2009
