Synchronous Isolated Distant Metastasis to Spleen From Colon Adenocarcinoma

Accepted 4 March 2009.

Summary

The most common site of metastasis from colorectal carcinoma is the liver. Isolated splenic metastasis from colorectal carcinomas is uncommon. We report a case of an 84-year-old man with synchronous isolated splenic metastasis from colon carcinoma. The splenic tumor was incidentally found by ultrasound and computer tomography. The patient underwent left hemicolectomy and splenectomy, and histology of spleen confirmed a metastatic adenocarcinoma from colonic carcinoma. The literature recommends close attention to the spleen in the patients with colonic carcinoma, and surgery may be possible in patients with isolated splenic metastasis.

Key Words: colorectal cancer , splenectomy , splenic metastasis

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Article Outline

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References

1. 1 Pedersen IK , Burcharth F , Roikjaer O , et al. Resection of liver metastases from colorectal cancer: indications and results . Dis Colon Rectum . 1994;37:1078–1082 . MEDLINE | CrossRef

2. 2 Eisenberg B , Decosse JJ , Harford F , et al. Carcinoma of the colon and rectum: the natural history reviewed in 1704 patients . Cancer . 1982;49:1131–1134 .

3. 3 Berge T . Splenic metastases: frequencies and patterns . Acta Pathol Microbiol Scand A . 1974;82:499–506 . MEDLINE

4. 4 Pisanu A , Ravarino A , Nieddu R , et al. Synchronous isolated splenic metastasis from colon carcinoma and concomitant splenic abscess: a case report and review of the literature . World J Gastroenterol . 2007;13:5516–5520 .

5. 5 Okuyama T , Oya M , Ishikawa H . Isolated splenic metastasis of sigmoid colon cancer: a case report . Jpn J Clin Oncol . 2001;31:341–345 . MEDLINE | CrossRef

6. 6 Bigot P , Goodman C , Hamy A , et al. Isolated splenic metastasis from colorectal cancer: report of a case . J Gastrointest Surg . 2008;12:981–982 . CrossRef

7. 7 Ishida H , Konno K , Ishida J , et al. Isolated splenic metastases . J Ultrasound Med . 1997;16:743–749 . MEDLINE

8. 8 Sappington SW . Carcinoma of the spleen: its microscopic frequency; a possible etiologic factor . J Am Med Assoc . 1922;78:953–955 .

9. 9 Kettle EH . Carcinomatous metastases in the spleen . J Pathol Bacteriol . 1913;17:40–46 . CrossRef

10. 10 Miller NJ , Milton GW . An experimental comparison between tumor growth in the spleen and liver . J Pathol Bacteriol . 1965;90:515–521 . MEDLINE | CrossRef

11. 11 Cavallaro A , Modugno P , Specchia M , et al. Isolated splenic metastasis from colon cancer . J Exp Clin Cancer Res . 2004;23:143–146 . MEDLINE

12. 12 Indudhara R , Vogt D , Levin HS , et al. Isolated splenic metastases from colon cancer . South Med J . 1997;90:633–636 . MEDLINE

13. 13 Weathers BK , Modesto VL , Gordon D . Isolated splenic metastasis from colorectal carcinoma: report of a case and review of the literature . Dis Colon Rectum . 1999;42:1345–1348 . MEDLINE | CrossRef

14. 14 Gencosmanoglu R , Aker F , Kir G , et al. Isolated metachronous splenic metastasis from synchronous colon cancer . World J Surg Oncol . 2006;4:42 .

15. 15 Place RJ . Isolated colon cancer metastasis to the spleen . Am Surg . 2001;67:454–457 . MEDLINE

16. 16 Thomas SM , Fitzgerald JB , Pollock RE , et al. Isolated splenic metastases from colon carcinoma . Eur J Surg Oncol . 1993;19:485–490 . MEDLINE

17. 17 Avesani EC , Cioffi U , De Simone M , et al. Synchronous isolated splenic metastasis from colon carcinoma . Am J Clin Oncol . 2001;24:311–312 . MEDLINE | CrossRef

a Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan

b Mackay Medicine, Nursing and Management College, Taipei, Taiwan

c Department of Pathology, Mackay Memorial Hospital, Taipei, Taiwan

d Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taitung, Taiwan

Correspondence to: Dr Ming-Jong Bair, Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, 1, Lane 303, Changsha Street, Taitung City, Taiwan

PII: S1873-9598(10)70007-7

doi:10.1016/S1873-9598(10)70007-7

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