International Journal of Gerontology
Volume 3, Issue 4 , Pages 197-203 , December 2009

Restless Legs Syndrome Among the Elderly

  • Pei-Hao Chen

      Affiliations

    • Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan
    • Mackay Medicine, Nursing and Management College, Taipei, Taiwan
  • ,
  • Shih-Jung Cheng

      Affiliations

    • Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan
    • Mackay Medicine, Nursing and Management College, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Shih-Jung Cheng, Department of Neurology, Mackay Memorial Hospital, Main Branch, 92, Section 2, Chungshan North Road, Taipei, Taiwan

,Accepted 1 December 2009.

References 

  1. Trenkwalder C , Högl B , Winkelmann J . Recent advances in the diagnosis, genetics and treatment of restless legs syndrome . J Neurol . 2009;256:539–553
  2. Milligan SA , Chesson AL . Restless legs syndrome in the older adult: diagnosis and management . Drugs Aging . 2002;19:741–751
  3. Cuellar NG , Strumpf NE , Ratcliffe SJ . Symptoms of restless legs syndrome in older adults: outcomes on sleep quality, sleepiness, fatigue, depression, and quality of life . J Am Geriatr Soc . 2007;55:1387–1392
  4. Mallon L , Broman JE , Hetta J . Restless legs symptoms with sleepiness in relation to mortality: 20-year follow-up study of a middle-aged Swedish population . Psychiatry Clin Neurosci . 2008;62:457–463
  5. Allen RP , Picchietti D , Hening WA , et al.   Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health . Sleep Med . 2003;4:101–119
  6. Ferri R , Lanuzza B , Cosentino FI , et al.   A single question for the rapid screening of restless legs syndrome in the neurological clinical practice . Eur J Neurol . 2007;14:1016–1021
  7. Hening WA , Allen RP , Washburn M , et al.   The four diagnostic criteria for Restless Legs Syndrome are unable to exclude confounding conditions (“mimics”) . Sleep Med . 2009;10:976–981
  8. Allen RP , Walters AS , Montplaisir J , et al.   Restless legs syndrome prevalence and impact: REST general population study . Arch Intern Med . 2005;165:1286–1292
  9. Tsuboi Y , Imamura A , Sugimura M , et al.   Prevalence of restless legs syndrome in a Japanese elderly population . Parkinsonism Relat Disord . 2009;15:598–601
  10. Whittom S , Dauvilliers Y , Pennestri MH , et al.   Ageat-onset in restless legs syndrome: a clinical and polysomnographic study . Sleep Med . 2007;9:54–59
  11. Ondo WG . Restless legs syndrome . Neurol Clin . 2009;27:779–799 vii.
  12. Lee JE , Shin HW , Kim KS , et al.   Factors contributing to the development of restless legs syndrome in patients with Parkinson disease . Mov Disord . 2009;24:579–582
  13. O'Keeffe ST . Secondary causes of restless legs syndrome in older people . Age Ageing . 2005;34:349–352
  14. Wang J , O'Reilly B , Venkataraman R , et al.   Efficacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: a randomized, double-blind, placebo-controlled study . Sleep Med . 2009;10:973–975
  15. Happe S , Vennemann M , Evers S , et al.   Treatment wish of individuals with known and unknown restless legs syndrome in the community . J Neurol . 2008;255:1365–1371
  16. Aukerman MM , Aukerman D , Bayard M , et al.   Exercise and restless legs syndrome: a randomized controlled trial . J Am Board Fam Med . 2006;19:487–493
  17. Hornyak M , Grossmann C , Kohnen R , et al.   Cognitive behavioral group therapy to improve patients scoping strategies with restless legs syndrome: a proof-of-concept trial . J Neurol Neurosurg Psychiatry . 2008;79:823–825
  18. Lettieri CJ , Eliasson AH . Pneumatic compression devices are an effective therapy for RLS: a prospective, randomized, double-blinded, sham-controlled trial . Chest . 2009;135:74–80
  19. Bayard M , Avonda T , Wadzinski J . Restless legs syndrome . Am Fam Physician . 2008;78:235–240
  20. Lee HB , Hening WA , Allen RP , et al.   Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the community . J Neuropsychiatry Clin Neurosci . 2008;20:101–105
  21. Rottach KG , Schaner BM , Kirch MH , et al.   Restless legs syndrome as side effect of second generation antidepressants . J Psychiatr Res . 2008;43:70–75
  22. Kim SW , Shin IS , Kim JM , et al.   Bupropion may improve restless legs syndrome: a report of three cases . Clin Neuropharmacol . 2005;28:298–301
  23. Silber MH , Ehrenberg BL , Allen RP , et al.   An algorithm for the management of restless legs syndrome . Mayo Clin Proc . 2004;79:916–922
  24. Trenkwalder C , Hening WA , Montagna P , et al.   Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice . Mov Disord . 2008;23:2267–2302
  25. Quilici S , Abrams KR , Nicolas A , et al.   Meta-analysis of the efficacy and tolerability of pramipexole versus ropinirole in the treatment of restless legs syndrome . Sleep Med . 2008;9:715–726
  26. von Spiczak S , Whone AL , Hammers A , et al.   The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study . Brain . 2005;128:906–917
  27. Walters AS , Wagner ML , Hening WA , et al.   Successful treatment of the idiopathic restless legs syndrome in a randomized double-blind trial of oxycodone versus placebo . Sleep . 1993;16:327–332
  28. Kushida CA , Becker PM , Ellenbogen AL , et al.   Randomized, double-blind, placebo-controlled study of XP13512/GSK1838262 in patients with RLS . Neurology . 2009;72:439–446
  29. Thorp ML , Morris CD , Bagby SP . A crossover study of gabapentin in treatment of restless legs syndrome among hemodialysis patients . Am J Kidney Dis . 2001;38:104–108
  30. Winkelmann J , Stautner A , Samtleben W , et al.   Long-term course of restless legs syndrome in dialysis patients after kidney transplantation . Mov Disord . 2002;17:1072–1076
  31. García-Borreguero D , Allen RP , Benes H , et al.   Augmentation as a treatment complication of restless legs syndrome: concept and management . Mov Disord . 2007;22(Suppl 18):S476–S484
  32. Allen RP , Ritchie SY . Clinical efficacy of ropinirole for restless legs syndrome is not affected by age at symptom onset . Sleep Med . 2008;9:899–902
  33. Walters AS , Winkelmann J , Trenkwalder C , et al.   Long-term follow-up on restless legs syndrome patients treated with opioids . Mov Disord . 2001;16:1105–1109

PII: S1873-9598(10)70001-6

doi: 10.1016/S1873-9598(10)70001-6

International Journal of Gerontology
Volume 3, Issue 4 , Pages 197-203 , December 2009