International Journal of Gerontology
Volume 3, Issue 2 , Pages 137-139 , June 2009

Valproic Acid-induced Agranulocytosis

  • Hui-Chuan Hsu

      Affiliations

    • Department of Pharmacy, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • ,
  • Hsiang-Kuang Tseng

      Affiliations

    • Infectious Disease Division, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • Institute of Tropical Medicine, National Yang-Ming University, Taipei, Taiwan
    • ,
  • Shen-Chuan Wang

      Affiliations

    • Department of Pharmacy, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • ,
  • Ying-Yue Wang

      Affiliations

    • Department of Pharmacy, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Ying-Yue Wang, Department of Pharmacy, Mackay Memorial Hospital, 92, Section 2, Chung-Shan North Road. Taipei 104, Taiwan

,Accepted 7 May 2009.

References 

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  2. Baehner RL . Drug-induced neutropenia and agranulocytosis. UpToDate Online 17.1 . Available at: http://www.utdol.com [Date accessed: 13 February 2009]
  3. Jaeken J , van Goethem C , Casaer P , Devlieger H , Eggermont E , Pilet M . Neutropenia during sodium valproate treatment . Arch Dis Child . 1979;54:986–987
  4. Kando JC , Tohen M , Castillo J , Zarate CA . The use of valproate in an elderly population with affective symptoms . J Clin Psychiatry . 1996;57:238–240
  5. O'Connor CR , Schraeder PL , Kurland AH , O'Connor WH . Evaluation of the mechanisms of antiepileptic drugrelated chronic leukopenia . Epilepsia . 1994;35:149–154
  6. Symon DN , Russell G . Sodium valproate and neutropenia . Arch Dis Child . 1983;58:235
  7. Vesta KS , Medina PJ . Valproic acid-induced neutropenia . Ann Pharmacother . 2003;37:819–821
  8. Storch DD . Severe leukopenia with valproate . J Am Acad Child Adolesc Psychiatry . 2000;39:1208–1209
  9. Watts RG , Emanuel PD , Zuckerman KS , Howard TH . Valproic acid-induced cytopenias: evidence for a doserelated suppression of hematopoiesis . J Pediatr . 1990;117:495–499
  10. Blackburn SC , Oliart AD , Garcia Rodriguez LA , Perez Gutthann S . Antiepileptics and blood dyscrasias: a cohort study . Pharmacotherapy . 1998;18:1277–1283
  11. Naranjo CA , Busto U , Sellers EM , Sandor P , Ruiz I , Roberts EA , et al.   A method for estimating the probability of adverse drug reactions . Clin Pharmacol Ther . 1981;30:239–245

PII: S1873-9598(09)70036-5

doi: 10.1016/S1873-9598(09)70036-5

International Journal of Gerontology
Volume 3, Issue 2 , Pages 137-139 , June 2009

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