International Journal of Gerontology
Volume 2, Issue 3 , Pages 140-142, September 2008

Thrombolytic Therapy in Acute Stroke

  • Yen-Wei Hsu

      Affiliations

    • Department of Neurology, Mackay Memorial Hospital, Hsinchu Branch, Hsinchu
  • ,
  • Chuan-Chuan Liu

      Affiliations

    • Department of Laboratory, Mackay Memorial Hospital, Taipei
  • ,
  • I-Fang Liu

      Affiliations

    • Department of Emergency Medicine, Mackay Memorial Hospital, Hsinchu Branch, Hsinchu, Taiwan
  • ,
  • Wai-Mau Choi

      Affiliations

    • Department of Emergency Medicine, Mackay Memorial Hospital, Hsinchu Branch, Hsinchu, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Wai-Mau Choi, Mackay Memorial Hospital, Hsinchu Branch, 690, Section 2, Guangfu Road, Hsinchu, Taiwan

Accepted 12 June 2008.

Article Outline

Summary 

Stroke as a cerebral dysfunction is strongly related to obstruction of cerebral perfusion. Thrombolytic agents have dramatic medical effects on reperfusion after cerebral infarction. Thus, early diagnosis and proper use of thrombolytic agents have become key events for successful treatment of stroke. We present a 63-year-old male patient who had sudden onset of left-sided weakness and slurred speech. After a prompt diagnosis and thrombolytic treatment, the patient was quickly restored from his neurologic defects and discharged without disability. Relevant literature is reviewed and discussed in the report.

Key Words:  stroke , thrombolytic therapy

No full text is available. To read the body of this article, please view the PDF online.

 

Back to Article Outline

References 

  1. Nishide M , Irino T , Gotoh M , Naka M , Tsuji K . Cardiac abnormalities in ischemic cerebrovascular disease studied by two-dimensional echocardiography . Stroke . 1983;15:541–545
  2. Duguid JB . The Dynamics of Atherosclerosis . Aberdeen: Aberdeen University Press; 1976;
  3. Ebrahim S , Harwood R . Stroke: Epidemiology, Evidence and Clinical Practice . Oxford: Oxford University Press; 1999;
  4. Fisher CM . Lacunar infarcts: a review . Cerebrovasc Dis . 1991;1:311–320
  5. Hacke W , Kaste M , Fieschi C , von Kummer R , Davalos A , Meier D , et al.   Randomised double-blind placebocontrolled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators . Lancet . 1998;352:1245–1251
  6. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group  . Tissue plasminogen activator for acute ischemic stroke . N Engl J Med . 1995;333:1581–1587
  7. Adams HP , Brott TG , Furlan AJ , Gomez CR , Grotta J , Helgason CM , et al.   Guidelines for thrombolytic therapy for acute stroke: a supplement to the guidelines for the management of patients with acute ischemic stroke: a statement for healthcare professionals from a Special Writing Group of the Stroke Council, American Heart Association . Circulation . 1996;94:1167–1174
  8. The NINDS t-PA Stroke Study Group  . Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke . Stroke . 1997;28:2109–2118
  9. Taiwan Stroke Society Consensus Group on Guidelines for rt-PA Use  . [Guidelines for the intravenous thrombolytic therapy in acute ischemic stroke.] . Nao Zhong Feng Hui Xun . 2003;10:4–11 [In Chinese].
  10. von Kummer R , Allen KL , Holle R , Bozzao L , Bastianello S , Manelfe C , et al.   Acute stroke: usefulness of early CT findings before thrombolytic therapy . Radiology . 1997;205:327–333
  11. Brott T , Lu M , Kothari R , Fagan SC , Frankel M , Grotta JC , et al.   Hypertension and its treatment in the NINDS rt-PA Stroke Trial . Stroke . 1998;29:1504–1509
  12. Murray CJL , Lopez AD . Mortality by cause for eight regions of the world: Global Burden of Disease Study . Lancet . 1997;394:1269–1276

PII: S1873-9598(08)70054-1

doi:10.1016/S1873-9598(08)70054-1

International Journal of Gerontology
Volume 2, Issue 3 , Pages 140-142, September 2008