International Journal of Gerontology
Volume 2, Issue 3 , Pages 124-127, September 2008

The Experience of a Novel Glycylcycline Antibiotic for a Patient with Infection Caused by Multiple Drug-Resistant Pathogens: What is the Benefit?

  • Po-Chin Chi

      Affiliations

    • Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • ,
  • Chien-Liang Wu

      Affiliations

    • Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • Division of Pulmonary and Critical Care Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • ,
  • Chung-Lieh Hung

      Affiliations

    • Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • Division of Cardiology, Mackay Memorial Hospital, Taipei, Taiwan
    • ,
  • Yu-Ling Weng

      Affiliations

    • Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • ,
  • Ching-Chi Lin

      Affiliations

    • Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • Mackay Medicine, Nursing and Management College, Taipei, Taiwan
    • ,
  • Shih-Yi Lee

      Affiliations

    • Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • Division of Pulmonary and Critical Care Medicine, Mackay Memorial Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Shih-Yi Lee, Department of Internal Medicine, 92, Section 2, Chung-Shan North Road, Taipei, Taiwan

Accepted 5 July 2008.

Article Outline

Summary 

We report a 75-year-old man with septic shock induced by ventilator-associated pneumonia caused by multiple drug-resistant Acinetobacter baumannii and catheter-related infection by vancomycin-resistant enterococci. He failed to respond to the initial management, including antibiotics (linezolid, imipenem, sulbactam and colistin) and hemodynamic-guided fluid challenge. However, his condition improved dramatically after the antibiotic regimen was changed to tigecycline and ceftazidime. In addition to the superiority of the antibacterial effect of tigecycline, fluid control can be achieved more easily while using a single antibiotic instead of multiple drugs, which is also important for care of a critically ill elderly man with compromised cardiorespiratory or renal function. Here, we present a patient infected with multiple drug-resistant pathogens, who improved clinically after being treated with tigecycline, to demonstrate the benefits of this antibiotic.

Key Words:  multiple antibacterial drug resistance , tigecycline , ventilator-associated pneumonia

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PII: S1873-9598(08)70050-4

doi:10.1016/S1873-9598(08)70050-4

International Journal of Gerontology
Volume 2, Issue 3 , Pages 124-127, September 2008

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