International Journal of Gerontology
Volume 1, Issue 1 , Pages 31-39 , March 2007

Updated Therapy in Elderly Patients with Knee Osteoarthritis

  • Der-Yuan Chen

      Affiliations

    • National Yang-Ming University, Taipei, Taichung, Taiwan
    • National Chung-Hsing University, Taichung, Taiwan
    • Department of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan
    • Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Der-Yuan Chen, Department of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, 160, Section 3, Taichung-Kang Road, Taichung 40705, Taiwan

,Accepted 30 November 2006.

References 

  1. (2005, 7 19) http://sowf.moi.gov.tw/04/07/.xls
  2. Centers for Disease Control and Prevention (CDC)  . Arthritis prevalence and activity limitations—United States, 1990 . MMWR Morb Mortal Wkly Rep . 1994;43:433–438
  3. Lawrence RC , Helmick CG , Arnett FC , Deyo RA , Felson DT , Giannini EH , et al.   Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States . Arthritis Rheum . 1998;41:778–783
  4. In:  Zhang Y ,  Xu L ,  Nevitt MC ,  Aliabadi P ,  Yu W ,  Qin M , et al. editor. Principles of Geriatric Medicine and Gerontology . 4 th edition. New York: McGraw Hill; 1999;p. 1097–1111
  5. Zhang Y , Xu L , Nevitt MC , Aliabadi P , Yu W , Qin M , et al.   Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study . Arthritis Rheum . 2001;44:2065–2071
  6. Messier SP , Loeser RF , Hoover JL , Semble EL , Wise CM . Osteoarthritis of the knee: effects on gait, strength, and flexibility . Arch Phys Med Rehab . 1992;73:29–36
  7. Tinetti ME , Inouye SK , Gill TM , Doucette JT . Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes . JAMA . 1995;273:1348–1353
  8. Ho SC , Woo J , Chan SS , Yuen YK , Sham A . Risk factors for falls in the Chinese elderly population . J Gerontol A Biol Sci Med Sci . 1996;51:M195–M198
  9. Creamer P , Hochberg MC . Osteoarthritis . Lancet . 1997;350:503–509
  10. Loeser RF . Aging and the etiopathogenesis and treatment of osteoarthritis . Rheum Dis Clin North Am . 2000;26:547–567
  11. Felson DT , Naimark A , Anderson J , Kazis L , Castelli W , Meenan RF . The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study . Arthritis Rheum . 1987;30:914–918
  12. Jordan JM , Luta G , Renner JB , Linder GF , Dragomir A , Hochberg MC , et al.   Self-reported functional status in osteoarthritis of the knee in a rural southern community: the role of sociodemographic factors, obesity, and knee pain . Arthritis Care Res . 1996;9:273–278
  13. Davis MA , Ettinger WH , Neuhaus JM , Hauck WW . Sex differences in osteoarthritis of the knee. The role of obesity . Am J Epidemiol . 1988;127:1019–1030
  14. Oliveria SA , Felson DT , Reed JI , Cirillo PA , Walker AM . Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization . Arthritis Rheum . 1995;38:1134–1141
  15. Felson DT , Zhang Y , Hannan MT , Naimark A , Weissman BN , Aliabadi P , et al.   The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study . Arthritis Rheum . 1995;38:1500–1505
  16. Felson D , Zhang Y . An update on the epidemiology of knee and hip osteoarthritis with a view to prevention . Arthritis Rheum . 1998;41:1343–1346
  17. Nevitt M , Felson D . Sex hormones and the risk of osteoarthritis in women: epidemiological evidence . Ann Rheum Dis . 1996;55:673–677
  18. Spector TD , Nandra D , Hart DJ , Doyle DV . Is hormone replacement therapy protective for hand and knee osteoarthritis in women? The Chingford study . Ann Rheum Dis . 1997;56:432–434
  19. Zhang Y , McAlindon TE , Hannan MT , Chaisson CE , Klein R , Wilson PW , et al.   Estrogen replacement therapy and worsening of radiographic knee osteoarthritis: the Framingham Study . Arthritis Rheum . 1998;41:1867–1873
  20. Felson DT , Anderson JJ , Naimark A , Walker AM , Meenan RF . Obesity and knee osteoarthritis. The Framingham Study . Ann Intern Med . 1988;109:18–24
  21. Felson DT , Zhang Y , Hannan MT , Naimark A , Weissman B , Aliabadi P , et al.   Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study . Arthritis Rheum . 1997;40:728–733
  22. McAlindon TE , Wilson PW , Aliabadi P , Weissman B , Felson DT . Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham study . Am J Med . 1999;106:151–157
  23. Roos H , Adalberth T , Dahlberg L , Lohmander LS . Osteoarthritis of the knee after injury to the anterior cruciate ligament or meniscus: the influence of time and age . Osteoarthritis Cartilage . 1995;3:261–267
  24. Roos H , Lauren M , Adalberth T , Roos EM , Jonsson K , Lohmander LS . Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls . Arthritis Rheum . 1998;41:687–693
  25. Slemenda C , Brandt KD , Heilman DK , Mazzuca S , Braunstein EM , Katz BP , et al.   Quadriceps weakness and osteoarthritis of the knee . Ann Intern Med . 1997;127:97–104
  26. Pai YC , Rymer WZ , Chang RW , Sharma L . Effect of age and osteoarthritis on knee proprioception . Arthritis Rheum . 1997;40:2260–2265
  27. Buckwalter J , Mankin H . Articular cartilage: Part II. Degeneration and osteoarthrosis, repair, regeneration, and transplantation . J Bone Joint Surg . 1997;79A:612–617
  28. Ryu J , Treadwell BV , Mankin HJ . Biochemical and metabolic abnormalities in normal and osteoarthritic human articular cartilage . Arthritis Rheum . 1984;27:49–54
  29. Pelletier JP , Martel-Pelletier J , Howell DS . Etiopathogenesis of osteoarthritis . In:  Koopman WJ editors. Arthritis and Allied Conditions: A Textbook of Rheumatology . 13 th edition. Baltimore: Williams & Wilkins; 1997;p. 1969
  30. Tortorella MD , Burn TC , Pratta MA , Abbaszade I , Hollis JM , Liu R , et al.   Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins . Science . 1999;284:1664–1666
  31. Dean DD , Martel-Pelletier J , Pelletier JP , Howell DS , Woessner JF . Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage . J Clin Invest . 1989;84:678–685
  32. Sharif M , Whitehouse A , Sharman P , Perry M , Adams M . Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3 . Arthritis Rheum . 2004;50:507–515
  33. Martin J , Ellerbroek S , Buckwalter J . Age-related decline in chondrocyte response to insulin-like growth factor-I: the role of growth factor binding proteins . J Orthop Res . 1997;15:491–497
  34. Guerne PA , Blanco F , Kaelin A , Desgeorges A , Lotz M . Growth factor responsiveness of human articular chondrocytes in aging and development . Arthritis Rheum . 1995;38:960–968
  35. Barone-Varelas J , Schnitzer TJ , Meng Q , Otten L , Thonar EJ . Age-related differences in the metabolism of proteoglycans in bovine articular cartilage explants maintained in the presence of insulin-like growth factor 1 . Connect Tissue Res . 1991;26:101–120
  36. Westacott CI , Sharif M . Cytokines in osteoarthritis: mediators or markers of joint destruction? . Semin Arthritis Rheum . 1996;25:254–260
  37. Dodge GR , Foole AR . Immunohistochemical detection and immunochemical analysis of type 2 collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin-1 . J Clin Invest . 1989;83:647–653
  38. Bailey A , Mansell J . Do subchondral bone changes exacerbate or precede articular cartilage destruction in osteoarthritis of the elderly? . Gerontology . 1997;43:296–301
  39. Carlson CS , Loeser RF , Purser CB , Gardin JF , Jerome CP . Osteoarthritis in cynomolgus macaques. III: Effects of age, gender, and subchondral bone thickness on the severity of disease . J Bone Miner Res . 1996;11:1209–1217
  40. Radin E , Paul I , Rose R . Role of mechanical factors in pathogenesis of primary osteoarthritis . Lancet . 1972;2:519–523
  41. Moskowitz RW , Holderbaum D . Clinical and laboratory findings in osteoarthritis . In:  Koopman WJ editors. Arthritis and Allied Conditions: A Textbook of Rheumatology . 13 th edition. Baltimore: Williams & Wilkins; 2001;p. 2216
  42. Schumacher HR , Gordon G , Paul H , Reginato AJ . Osteoarthritis, crystal deposition, and inflammation . Semin Arthritis Rheum . 1971;1:116–120
  43. Altman R , Asch E , Bloch D , Bole G , Borenstein D , Brandt K , et al.   Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association . Arthritis Rheum . 1986;29:1039–1049
  44. Jordan KM , Arden NK , Doherty M , Bannwarth B , Bijlsma JW , Dieppe P , et al.   EULAR Recommendations 2003: an evidence-based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT) . Ann Rheum Dis . 2003;62:1145–1155
  45. Hochberg MC , Altman RD , Brandt KD , Clark BM , Dieppe PA , Griffin MR , et al.   Guidelines for the medical management of osteoarthritis. Part II. Osteoarthritis of the knee. American College of Rheumatology . Arthritis Rheum . 1995;38:1541–1546
  46. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines  . Recommendation for the medical management of osteoarthritis of the hip and knee: 2000 update . Arthritis Rheum . 2000;43:1905–1915
  47. Felson DT , Zhang Y , Anthony JM , Naimark A , Anderson JJ . Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study . Ann Intern Med . 1992;116:535–539
  48. Fisher NM , Gresham GE , Abrams M , Hicks J , Horrigan D , Pendergast DR . Quantitative effects of physical therapy on muscular and functional performance in subjects with osteoarthritis of the knees . Arch Phys Med Rehabil . 1993;74:840–847
  49. Fiatarone MA , Marks EC , Ryan ND , Meredith CN , Lipsitz LA , Evans WJ . High-intensity strength training in nonagenarians. Effects on skeletal muscle . JAMA . 1990;263:3029–3034
  50. Morganti CM , Nelson ME , Fiatarone MA , Dallal GE , Economos CD , Crawford BM , et al.   Strength improvements with 1 year of progressive resistance training in older women . Med Sci Sports Exerc . 1995;27:906–912
  51. Ettinger WH , Burns R , Messier SP , Applegate W , Rejeski WJ , Morgan T , et al.   A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST) . JAMA . 1997;277:25–31
  52. Exercise prescription for older adults with osteoarthritis pain  . consensus practice recommendations. A supplement to the AGS Clinical Practice Guidelines on the management of chronic pain in older adults . J Am Geriatr Soc . 2001;49:808–813
  53. Rene J , Weinberger M , Mazzuca SA . Reduction of joint pain in patients with knee osteoarthritis who have received monthly telephone calls from lay personnel and whose medical treatment regimens have remained stable . Arthritis Rheum . 1992;35:511–516
  54. Weinberger M , Hiner SL , Teirney WM . Improving functional status in arthritis: the effect of social support . Soc Sci Med . 1986;23:899–905
  55. Lin EH , Katon W , Von Korff M , Tang L , Williams JW , Kroenke K , et al.   Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial . JAMA . 2003;290:2428–2429
  56. Fransen M , Crosbie J , Edmonds J . Physical therapy is effective for patients with osteoarthritis of the knee: a randomized controlled clinical trial . J Rheumatol . 2001;28:156–161
  57. Huang MH , Lin YS , Lee CL , Yang RC . Use of ultrasound to increase effectiveness of isokinetic exercise for knee osteoarthritis . Arch Phys Med Rehabil . 2005;86:1545–1551
  58. Draper ER , Cable JM , Sanchez-Ballester J , Hunt N , Robinson JR , Strachan RK . Improvement in function after valgus bracing of the knee. An analysis of gait symmetry . J Bone Joint Surg Br . 2000;82:1001–1005
  59. Bradley JD , Brandt KD , Katz BP , Kalasinski LA , Ryan SI . Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee . N Engl J Med . 1991;325:87–91
  60. Williams HJ , Ward JR , Egger MJ , Neuner R , Brooks RH , Clegg DO , et al.   Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee . Arthritis Rheum . 1993;36:1196–1206
  61. American Geriatrics Society Panel on Chronic Pain in Older Persons  . The management of chronic pain in older persons . J Am Geriatr Soc . 1998;46:635–639
  62. Raffa RB , Friderichs E . The basic science aspect of tramadol hydrochloride . Pain Rev . 1996;3:249–271
  63. Emkey R , Rosenthal N , Wu SC , Jordan D , Kamin M , CAPSS-114 Study Group  . Efficacy and safety of tramadol/ acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial . J Rheumatol . 2004;31:150–156
  64. Bellamy N , Campbell J , Robinson V , Gee T , Bourne R , Wells G . Intra-articular corticosteroid for treatment of osteoarthritis of the knee . Cochrane Database Syst Rev . 2006;2:CD005328
  65. Arroll B , Goodyear-Smith F . Corticosteroid injections for osteoarthritis of the knee: meta-analysis . BMJ . 2004;328:869–874
  66. Fries J , Williams C , Bloch D . The relative toxicity of nonsteroidal anti-inflammatory drugs . Arthritis Rheum . 1991;34:1353–1358
  67. Smalley WE , Ray WA , Daugherty JR , Griffin MR . Nonsteroidal anti-inflammatory drugs and the incidence of hospitalizations for peptic ulcer disease in elderly persons . Am J Epidemiol . 1995;141:539–545
  68. Gurwitz JH , Avorn J , Ross-Degnan D , Lipsitz LA . Nonsteroidal anti-inflammatory drug-associated azotemia in the very old . JAMA . 1990;264:471–475
  69. Hawkey CJ . COX-2 inhibitors . Lancet . 1999;353:307–314
  70. Singh G , Fort JG , Goldstein JL , Levy RA , Hanrahan PS , Bello AE , et al.   Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-1 Study . Am J Med . 2006;119:255–266
  71. Bjordal JM , Ljunggren AE , Klovning A , Slordal L . Nonsteroidal anti-inflammatory drugs, including cyclooxygenase-2 inhibitors, in osteoarthritic knee pain: meta-analysis of randomized placebo-controlled trials . BMJ . 2004;329:1317
  72. Mamdani M , Rochon PA , Juurlink DN , Kopp A , Anderson GM , Naglie G , et al.   Observational study of upper gastrointestinal haemorrhage in elderly patients given selective cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs . BMJ . 2002;325:624
  73. Yen ZS , Lai MS , Wang CT , Chen LS , Chen SC , Chen WJ , et al.   Cost-effectiveness of treatment strategies for osteoarthritis of the knee in Taiwan . J Rheumatol . 2004;31:1797–1803
  74. Couzin J . Drug safety. Withdrawal of Vioxx casts a shadow over COX-2 inhibitors . Science . 2004;306:384–385
  75. Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, et al  Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial . N Engl J Med . 2005;352:1092–1102
  76. Lin J , Zhang W , Jones A , Doherty M . Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomized controlled trials . BMJ . 2004;329:324–327
  77. Deal CL , Schnitzer TJ , Lipstein E , Seibold JR , Stevens RM , Levy MD , et al.   Treatment of arthritis with topical capsaicin: a double-blind trial . Clin Ther . 1991;13:383–395
  78. Verbruggen G . Chondroprotective drugs in degenerative joint diseases . Rheumatology (Oxford) . 2006;45:129–138
  79. Brandt KD , Mazzuca SA , Katz BP , Lane KA , Buckwalter KA , Yocum DE , et al.   Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebocontrolled, double-blind trial . Arthritis Rheum . 2005;52:2015–2025
  80. Brandt KD , Mazzuca SA . Experience with a placebocontrolled, randomized clinical trial of a diseasemodifying drug for osteoarthritis: the doxycycline trial . Rheum Dis Clin North Am . 2006;32:217–234
  81. Richy F , Bruyere O , Ethgen O , Cucherat M , Henrotin Y , Reginster JY . Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis . Arch Intern Med . 2003;163:1514–1522
  82. Towheed TE , Maxwell L , Anastassiades TP , Shea B , Houpt J , Robinson V , et al.   Glucosamine therapy for treating osteoarthritis . Cochrane Database Syst Rev . 2005;2:CD002946
  83. Michel BA , Stucki G , Frey D , De Vathaire F , Vignon E , Bruehlmann P , et al.   Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trial . Arthritis Rheum . 2005;52:779–786
  84. Clegg DO , Reda DJ , Harris CL , Klein MA , O'Dell JR , Hooper MM , et al.   Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis . N Engl J Med . 2006;354:795–808
  85. Spencer CM , Wilde MI . Diacerein . Drugs . 1997;53:98–107
  86. Pelletier JP , Mineau F , Fernandes JC , Duval N , MartelPelletier J . Diacerhein and rhein reduce the interleukin 1-beta-stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritis chondrocytes . J Rheumatol . 1998;25:2417–2424
  87. Yaron M , Shirazi I , Yaron I . Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritis synovial tissue and cartilage cultures . Osteoarthritis Cartilage . 1999;7:272–278
  88. Fidelix TS , Soares BG , Trevisani VF . Diacerein for osteoarthritis . Cochrane Database Syst Rev . 2006;1:CD005117
  89. Cake MA , Read RA , Guillou B , Ghosh P . Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables (ASU) . Osteoarthritis Cartilage . 2000;8:404–411
  90. Ernst E . Avocado-soybean unsaponifiables (ASU) for osteoarthritis—a systematic review . Clin Rheumatol . 2003;22:285–288
  91. Abatangelo G , O'Regan M . Hyaluronan: biological role and function in articular joints . Eur J Rheumatol Inflamm . 1995;15:9–16
  92. Takahashi K , Hashimoto S , Kubo T , Hirasawa Y , Lotz M , Amiel D . Effect of hyaluronan on chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis . J Rheumatol . 2000;27:1713–1720
  93. Adams ME , Atkinson MH , Lussier AJ , Schulz JI , Siminovitch KA , Wade JP , et al.   The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with nonsteroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone . Osteoarthritis Cartilage . 1995;3:213–225
  94. Day R , Brooks P , Conaghan PG , Petersen M , Multicenter Trial Group  . A double-blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee . J Rheumatol . 2004;31:775–782
  95. Dieppe P , Basler HD , Chard J , Croft P , Dixon J , Hurley M , et al.   Knee replacement surgery for osteoarthritis: effectiveness, practice variations, indications and possible determinants of utilization . Rheumatology (Oxford) . 1999;38:73–83

PII: S1873-9598(08)70021-8

doi: 10.1016/S1873-9598(08)70021-8

International Journal of Gerontology
Volume 1, Issue 1 , Pages 31-39 , March 2007

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