International Journal of Gerontology
Volume 1, Issue 1 , Pages 22-30, March 2007

Current Opinion on the Clinical Approach to the Diagnosis of Mitochondrial Disease

  • Peterus Thajeb

      Affiliations

    • Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan
    • National Yang-Ming University School of Medicine, Taipei, Taiwan
    • Taipei Medical University, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Peterus Thajeb, Mackay Memorial Hospital, National Yang-Ming University School of Medicine, and Taipei Medical University, PO Box Nei-hu 6-30, Taipei 11499, Taiwan
    • ,
  • Dao-Fu Dai

      Affiliations

    • Department of Pathology, University of Washington School of Medicine, Seattle, USA

Accepted 11 November 2006.

SUMMARY 

Knowing the molecular basis of mitochondria, the aging process of the mitochondrial machinery and recognition of its disorders are becoming more important in modern medicine. The diagnosis of mitochondrial disease (MtD) is possible only when one is aware of it. The heterogeneity of MtD in terms of its phenotype expression and genotype variations makes MtD very unique. Current opinion on the clinical approach to patients with suspected mitochondrial disorders are highlighted in this review.

Key Words:  aging , mitochondrial disease , mitochondrial DNA , mutation , nuclear DNA , oxidative phosphorylation

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PII: S1873-9598(08)70020-6

doi:10.1016/S1873-9598(08)70020-6

International Journal of Gerontology
Volume 1, Issue 1 , Pages 22-30, March 2007

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