International Journal of Gerontology
Volume 1, Issue 1 , Pages 10-21, March 2007

Therapeutic Application of Bone Marrow-derived Progenitor Cells for Vascular Diseases: Magicbullets Having the Good Without the Bad?

  • Kimie Tanaka

      Affiliations

    • Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    • ,
  • Masataka Sata

      Affiliations

    • Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    • Department of Advanced Clinical Science and Therapeutics, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    • Corresponding Author InformationCorrespondence to: Dr Masataka Sata, Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8655, Japan

Accepted 28 November 2006.

SUMMARY 

Accumulating evidence suggests that bone marrow-derived progenitor cells contribute to vascular healing and remodeling under physiologic and pathologic conditions. Although there is growing enthusiasm for therapeutic and diagnostic application of bone marrow-derived progenitors, there is a possibility that transplanted precursors or bone marrow cells may participate in the pathogenesis of unexpected diseases such as cancer, retinopathy, and atherosclerosis. The aim of this article is to review recent findings on bone marrow-derived progenitor cells obtained from animal models and clinical trials.

Key Words:  atherosclerosis , endothelial cells , progenitors , smooth muscle cells , stem cell

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PII: S1873-9598(08)70019-X

doi:10.1016/S1873-9598(08)70019-X

International Journal of Gerontology
Volume 1, Issue 1 , Pages 10-21, March 2007

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